People with serious mental illness suffer significantly higher rates of chronic medical conditions than the general population and die, on average, 25 years younger. These increased levels of morbidity and mortality are largely due to preventable causes including a high prevalence of modifiable risk factors, a lack of adequate preventative care, and the side effects of some psychiatric medicines. Chronic medical illness is a major obstacle to recovery from serious mental illness. Mental health providers have a responsibility to ensure that their clients have access to preventive healthcare, and to contribute to the integration of their clients’ behavioral and medical care.